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Concerns have been raised about the safety of hydroquinone in Europe, Japan, and the USA due to: Other reported cutaneous adverse effects of hydroquinone include: The safety of topical hydroquinone has not been established in pregnancy and lactation

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The reduction of roGFP2(S 2 ) according to monothiol mechanism (iii) and previous experiments in yeast also raise the question whether the dithiol mechanism is crucial for the reduction of many protein substrates 34

Another 7 families did not continue for personal reasons unrelated to the study