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Klingenberg M, Matsuda A, Diederichs S, Patel T

Jun 28 2016;21(7)doi:10.3390/molecules21070844 Almaghrabi S, Adams M, Geraghty D, Ahuja K

Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000

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It should be noted that recent studies have shown convergence between these two pathways such that AMPK activation is an upstream event of the NRF2-mediated antioxidant response 53

Meanwhile, the results of Western blot assay showed that the protein expression levels of Cyclin A2 , Cyclin E2 , c-MYC , Cyclin D1 and CDK2 were significantly increased in the RRM2 overexpression group, and Cyclin D1 , Cyclin E1/E2 and Cyclin A2 are important regulators driving the cell cycle process, and their high expression is often associated with the acceleration of G1/S phase transition