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In animal studies, in comparison to a control diet, HFD consumption resulted in increased hepatic IKK--SSG formation, leading to suppressed IKK- activation and subsequent NF-B suppression

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One patient was reported to have learning disability with dyslexia and was also thought to be mentally retarded [5], and another had delayed psychomotor development and progressive sensory neuropathy of lower extremities, ataxia, hyperreflexia, dysarthria, and a peculiar gait suggestive of spinocerebellar degeneration [2]