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The main sources of sulfur-rich foods are cruciferous vegetables and allium vegetables like onions, garlic, shallots, and leeks

The mutation rate was set to 5 10 9 substitutions per site per year (40), and 15 years per generation was assumed

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Consequently, we delve into the molecular mechanisms through which 16-OHE promotes PH, encompassing induction of oxidative stress, enhancement of proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) and pulmonary arterial endothelial cells (PAECs), promotion of metabolic abnormalities, induction of endothelial mesenchymal transition (EndoMT), and fostering inflammation (Fig