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TRIM proteins and diseases

In the development of an infection, infectious agents develop inflammatory responses during which some cells of the immune system produce cytotoxic compounds that act like ROS to attack the pathogen but that can also harm the host [11, 12]

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Zhao Y, Seefeldt T, Chen W, Carlson L, Stoebner A, Hanson S, et al

The unexpected activity can be explained by the formation of variable amounts of disulfide-bridged PfGrx C32S/C88S homodimers and potential Diamide-modified monomers, summarized as PfGrx C32S/C88S (SX), as revealed by non-reducing SDS-PAGE (Fig