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We fully describe the common and specific features of these two types of redox relays, and use their oxidation kinetics to define the H 2 O 2 intracellular gradients, the cellular scavenging activities governing at different peroxide ranks, the redox state of the Trx-reducing system, and the status of both signaling cascades

A newer mnemonic, GOLDMARK (Table 1), includes more common clinically important causes of AG metabolic acidosis 2

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ARE-dependent enzymes include CAT and SOD, and other enzymes that catalyze the oxidation and conjugation of carcinogens and oxidants for excretion