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Three SAM molecules are required for the methylation of phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase (PEMT)

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While initial nuclear magnetic resonance (NMR) studies indicated that apoC1 is composed of two amphipathic -helices (residues 729 and 3852) [36] more recent investigations using X-ray diffraction on apoC1 crystals suggest that the whole molecule can form a single -helix [37] (Fig