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Less Common and Serious Side Effects While rare, there are more significant adverse effects of NAD IV therapy that should not be overlooked: Anaphylactoid or allergic reactions: Skin rash, bronchospasm, or low blood pressure in sensitive individuals Sudden, significant rises in inflammation markers (hs-CRP), seen in up to 70% of patients Glucose intolerance or signs of liver toxicity, especially with concurrent oral NAD supplementation or long-term use Injection site infection: Redness, excessive swelling, warmth, or pus at the administration site Exacerbation of underlying mood disorders or confusion These serious risks are much less common with a single, medically supervised NAD infusion, but high doses, frequent treatments, or improper administration, particularly outside of a trained medical office, raise the likelihood dramatically

Tracks both protocol efficacy and excess GH exposure (elevated IGF-1 above age-adjusted ranges warrants dose adjustment) Fasting glucose and insulin (HOMA-IR): GH is counter-regulatory to insulin

Crystal structure of a lipid G protein-coupled receptor

Clinical and animal data demonstrate variable yet typically favorable shifts in LH/FSH with GHS, particularly in the context of baseline deficiency or metabolic comorbidities

does not significantly affect cortisol or prolactin

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