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Hyperactivation of STAT3 enhances the production of proinflammatory cytokines, including interleukin (IL)-6 and IL-23, promoting the senescence-associated secretory phenotype (SASP) and sustaining inflammatory signaling

Under physiological conditions, a healthy gut microbiota and an intact intestinal barrier are critical for establishing immune tolerance ( The tumor immune microenvironment (TIME), a dynamic ecosystem of cancer cells, stromal cells, ECM, and diverse immune cells, profoundly shapes tumor progression and therapeutic responses ( A pivotal mechanism linking gut dysbiosis to pro-tumorigenic inflammation is the translocation of microbial components, most notably lipopolysaccharide (LPS), across a compromised intestinal barrier ( Beyond TLR-dependent microbial sensing, the NF-B pathway serves as a critical signaling hub that integrates diverse pro-tumorigenic stimuli within the TIME

Deze verbeterde vorm zorgt ervoor dat meer glutathion direct beschikbaar is om cellen te verdedigen tegen de schadelijke effecten van vrije radicalen en andere toxines

5.2 Vitamin C and ASD Vitamin C is a powerful antioxidant capable of counteracting and eliminating ROS produced during metabolic processes (Figueroa-Mndez and Rivas-Arancibia, 2015)

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