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Enhanced immune cell infiltration and activation were observed, Marked by a 2.6-fold increase in CD 45+ lymphocytes, a 3.6-fold increase in CD 3+ T cells, and elevated levels of IFN- and TNF

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DKK family members (DKK1, DKK2 and DKK3) exhibit the ability to block Wnt signaling and inhibit cell growth and metastasis (Hirata et al., 2011