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3 However, the relative insufficiency of H 2 O 2 and overexpressed intracellular glutathione (GSH) in TME restrict the anticancer effect of CDT

HMTs such as CARM1, G9a, and EZH2 control ATG transcription through H3R17, H3K9, or H3K27 methylation, linking chromatin to nutrient and stress cues

Fortuna, A

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively

These molecular changes contribute to cell protection through multiple synergistic mechanisms: (1) Reduced Ang II levels lead to reduced NADPH oxidase activity and reduced ROS generation, thereby alleviating oxidative stress

For instance, flavonoids are able to stabilize cell membranes and prevent lipid peroxidation, thereby preserving cellular integrity (Vieira Gomes et al., 2019)