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Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials

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She had been diagnosed with RA (ANA+, RF+, CCP-) two years earlier and treated with renally dosed MTX (10 mg) weekly and daily folic acid supplementation with a 1 mg dose