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Our laboratory utilizes a developmental toxicant exposure model created by exposing pregnant C57/BL6 mice (F0, or founding generation) to a single 10 g/kg dose of TCDD by oral gavage on embryonic day 15.5 providing in utero and lactational exposures of TCDD to offspring (F1 generation) (Nayyar et al., 2007)

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[15] Hypersensitivity reactions including anaphylaxis or anaphylactoid reactions and allergic skin reactions may occur with tranexamic acid use

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The principal mediator of this homeostatic response is hypoglycosylated EPO produced in situ by many cells as a stress response