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Using individual variation in GSH combined with a repeated measures approach is a highly effective form of randomization

doi: 10.1016/j.molmed.2022.02.003 12 TuHZhouYJTangLJXiongXMZhangXJAli SheikhMSet al

For example, some gut microbes have the ability to remove iodine atoms in hormones, which may lead to the inhibition of the synthesis and secretion of thyroid hormones (Khrle et al., 1987)

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however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages