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2001 Feb 9;276(6):4365-72

Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

Ascorbic Acid (Vitamin C) Injection is primarily used to treat or prevent vitamin C deficiency in patients unable to take oral supplements, or in clinical situations where higher plasma concentrations are required, such as certain infections, wound healing, or adjunctive therapy in specific protocols

Asanuma, M., & Miyazaki, I

In response to light exposure, both euthymic and actively affected bipolar patients manifest two-fold greater reduction of nocturnal plasma melatonin concentrations compared with the healthy controls (181, 182, 186)

This is manifested by insufficient infiltration of antigen-presenting cells (APCs), which results in the failure to effectively capture DAMPs (e.g., ATP, HMGB1) released by dying tumor cells, thereby inhibiting cross-presentation of antigens and activation of cytotoxic T lymphocytes (CTLs) (82)