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Most newly developed pharmacon candidates to treat neurological diseases are not able to cross the BBB and reach their target(s) within the brain [3]

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Mice were fed either a control (Research Diets, D21050401) or 10% (gm%) inulin diet (Research Diets, D21050402)

Cat#76-0002 & Cat#76-0702) and STARTLE software module (PACKWIN-CSST, PACKWIN version 2.0

In this assay, the 30 min incubation duration was chosen to be optimal because of the inherently cytotoxic nature of CuCl 2 and Cu(OAc) 2 towards HaCaT keratinocytes, as they were observed to cause substantial cell death at a duration longer than 30 mins

The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript