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In rare cases, it may be associated with a severe hepatotoxicity

Additionally, histone lactylation has been shown to promote medial calcification both in vitro and in vivo

HarrisonSARinellaMEAbdelmalekMFTrotterJFParedesAHArnoldHLet alNGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

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This process, called protein succination, is a feature of FH-deficient tumour tissues, where fumarate accumulates to millimolar levels 6