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Four years later, Betzel et al

Improves skin tone and texture

A topical cosmetic may support hydration, texture and firmness, but permanent wrinkle removal is not a responsible promise

For example, mutations in the IVD gene encoding the enzyme for leucine degradation cause isovaleric acidemia, in which the intermediate isovaleric acid accumulates and damages the brain and nervous system (Vockley and Ensenauer, 2006)