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Nienhuis AW, Persons DA

The Phase III REDEFINE 4 trial marked the first direct comparison between leading obesity treatments: 84-week, open-label, randomized study CagriSema (cagrilintide 2.4mg + semaglutide 2.4mg) vs Tirzepatide 15mg 809 adults with obesity (BMI 30), mean baseline weight 114.2 kgs Primary endpoint: relative percent change in body weight at week 84 Weight loss results under efficacy estimand (AKA only the people that stayed adherent): CagriSema: 23.0% Zepbound: 25.5% Weight loss results under treatment regimen estimand (AKA everyone in the trial, regardless of adherence): CagriSema: 20.2% Zepbound: 23.6% CagriSema failed to meet non-inferiority to Zepbound in this trial

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These SODs are found in different cell compartments and in all biological kingdoms in an uneven distribution

Pins and needles, muscle weakness, recurring headaches, or feeling faint are all potential red flags

Results vary, so supplements should be combined with sunscreen, balanced nutrition and consistent skincare