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The advent of single-cell transcriptomics, proteomics, and metabolomics technologies now enables unprecedented resolution in analyzing EC heterogeneity and metabolic dynamics in vivo

However, an emerging conceptual shift suggests that lipid peroxidation and ferroptosis significantly contribute to FRDA pathogenesis, acting in concert with other well-established disease mechanisms such as mitochondrial bioenergetic failure, apoptosis, and inflammatory signaling [29,30]

Mult Scler J 9:540549

Next, cDNA was transcribed using the Super Script III Reverse Transcriptase kit (Life Technologies, Switzerland)

In TM cells, after exogenous oxidative treatment, the following damage has been observed: a decrease in cellular activity (102), a change in cell cycle progression, the inhibition of cell proliferation (103), and the promotion of cellular senescence (100)