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doi: 10.1136/annrheumdis-2014-207169 43

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Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation

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FIGURE 2 4.1 Ferroptosis promotes pancreatic tumour and hepatocellular carcinoma development and progression by regulating metabolic pathways ACSL4, an enzyme involved in synthesizing phospholipids from PUFAs plays a crucial role in ferroptosis (Yuan et al., 2016)

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Increasing extracellular glutamate levels limits the uptake of cystine, gradually inducing ferroptosis

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Nakamura Y, Feng Q, Kumagai T et al (2002) Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant

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