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While enhanced alcohol metabolism may seem protective, elevated CYP2E1 accelerates ethanol oxidation, resulting in higher acetaldehyde production and excessive reactive oxygen species (ROS) generation, including hydroxyethyl radicals, superoxide anions, and hydroxyl radicals [27, 28]

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While the FDA notes that compounded medications do not undergo pre-market approval for safety and efficacy, proponents argue that heavily regulated 503A and 503B compounding pharmacies ensure product potency and sterility

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Hartlieb, S

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10.1038/nrd3074 Takimoto H, Machida K, Ueki M, Tanaka T, Taniguchi M: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp

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In the brain, hyperglycaemia activates microglia, and microglia activation and polarisation can mediate central inflammatory responses, neuronal apoptosis and exacerbate central neuropathy leading to dementia (28)

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