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added that APOE- 4 is a risk factor, and that patients that are homozygous to this allele will be 8 times more prone to develop AD (Yokoyama et al., 2017)

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The application of multi-OMICS approaches are gaining acceptance in the regulatory community to provide information on a chemicals hazard and risks though their mode-of-action (MOA), however, its utility in a AOP building context are still limited

Chronobiological studies have shown that RSV decreases lipid peroxidation when administered during the dark phase but increases it during the light phase, highlighting the importance of timing in its therapeutic application (24)

In skin cell and animal research models, it has been studied for its ability to upregulate the genes responsible for producing collagen and elastin - the structural proteins that give tissue its strength and elasticity