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Similarly, an in vitro study (Nan et al., 2014) using bovine mammary cells demonstrated that Lys, Met, and a combination of these amino acids (especially in a 3:1 Lys: Met ratio) positively regulated the expression of genes associated with the JAK2-STAT5 and mTOR pathway, and increased casein concentration, suggesting a potential effect on enhancing milk protein synthesis

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Methylation of the CpG islands in the NRF2 gene promoter typically suppresses NRF2 transcriptional activity, leading to reduced expression levels and impacting the cells antioxidant functions [148]

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Although not yet fully understood, the likely cause is the ionizing UV radiation spectrum of sunlight

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