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Injections of methotrexate can be administered intramuscularly (into a muscle), intravenously (into a vein), subcutaneously (just beneath the skin), or intrathecally (into the spinal canal's fluid-filled space) as a powder that has been combined with liquid

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In the forced swim test (FST), each animal swam for 6 minutes, and the immobility time was recorded during the last 4 minutes of the session

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