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Gabriele Antonini Acknowledgments Ethical approval: All procedures performed in this study were in accordance with the ethical standards of our institutions and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

Animal studies have demonstrated that type 1 diabetes mellitus (T1DM) can lead to testicular atrophy, disruption of seminiferous tubule architecture, and impaired spermatogenesis through multiple mechanisms, including oxidative stress, apoptosis, endocrine dysregulation, autoimmune responses, and epigenetic alterations [4, 5]

Though promising, research into vitamins and supplements to treat ED is still in its infancy

167, 1997, pp

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*Correspondence: Richard Eugene Frye, Arkansas Childrens Hospital Research Institute, Slot 512-41B, 13 Childrens Way, Little Rock, AR 72202, USA e-mail: [email protected] This article was submitted to Child and Neurodevelopmental Psychiatry, a section of the journal Frontiers in Pediatrics