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Through the integrated function of these domains, STAT5 serves as a critical node in cytokine-induced intracellular signal transduction and nuclear transcriptional regulation ( Collectively, activation of the long-form prolactin receptor (PRLR) initiates the canonical JAK2/STAT5 signaling cascade, which is the principal pathway underlying the diverse biological actions of PRLR ( 2.3 Metabolic effects of physiological hyperprolactinemia in pregnancy and lactation Physiological elevations in prolactin levels, including pituitary-derived prolactin and placental lactogen, preferentially induce hypothalamic leptin resistance in females, thereby promoting increased caloric intake and gestational weight gain

power = 80% Randomization Intervention allocation was done by using a random number list and eligible patients were randomly allocated to trial groups in a ratio of 1:1

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