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Dependent on the TREM2-APOE pathway, microglia lose the expression of genes encoding homeostatic molecular profile (P2ry12, Tmem119, Csf1r, Hexb, Mertk, Cx3cr1) and upregulate the expression of inflammatory genes (Apoe, Itgax, Ccl2, Clec7a, Axl)

BPC157 A synthetic peptide sequence that has been widely referenced in laboratory studies exploring connective signaling pathways and other molecular mechanisms

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Antioxidants inhibit oxidation and prevent or delay cell damage (42)

10.1016/j.ijdevneu.2008.09.005 186 McDonaldR

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