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However, lower systemic exposure from oral delivery is not automatically "safer," since under-dosed compounds may still carry unknown long-term risks without providing benefit

Dec 2016;32(6):557-564

[DOI] [PubMed] [Google Scholar] 75.Sarandol A., Sarandol E., Eker S.S., Erdinc S., Vatansever E., Kirli S

doi: 10.1079/NRR200238 40 ZafalonRVRisoliaLWPedrinelliVVendraminiTHRodriguesRBAmaralARet al

This top-down control of metabolic protein expression and function through signal transduction and gene transcription is essential for establishing a framework through which biochemicals can be produced and consumed