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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

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Effective dosing ranged between 0.25 and 2.0 mg/kg/day ( The serotonergic 5-HT 4 receptor agonist, cisapride, was associated with symptomatic benefit in patients with gastroparesis based on short-or medium-term placebo-controlled trials ( Other medications available in a few countries, clebopride, cinitapride, and mosapride, are not reviewed in detail here in view of the relatively weak evidence of efficacy in gastroparesis

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Marian also recently entered the fashion scene with her newly established clothing line, Flora Vida