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On the other hand, free radicals directly degrade the joint cartilage by targeting its proteoglycan and restricting its synthesis

Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects

And it's naturally found in your body

doi: 10.1046/j.1365-2265.1997.2601068.x

Liu Y, Qian X, Ran C, Li L, Fu T, Su D, et al

Oxidative Stress and Hair Follicle Damage Research indicates that aspartame metabolites generate free radicals that can damage hair follicles at the cellular level [3]