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The manifestation of oxidative stress incites lipid peroxidation, which is concomitant with a decrease in GPx concentrations and a decline in the activity of antioxidant enzymes

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In the previous studies, Hong et al (245) reviewed the role of ferroptosis, a newly discovered form of programmed cell death characterized by iron-dependent lipid peroxidation, in cardiovascular diseases (CVDs)

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Several in vitro studies described below have demonstrated acrolein-induced alterations in cellular mitogen activated protein kinases (MAPKs) which are likely to contribute to other mechanisms of toxicity