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gasseri can ameliorate DSS-induced colitis by inhibiting ferroptosis

As summarized earlier, ferroptosis arises from a dysregulated balance between pro-ferroptotic cues (e.g., labile iron accumulation and PUFA enrichment) and protective mechanisms, including the SLC7A11GSHGPX4 axis, GCH1BH4 pathway, FSP1CoQH2 system, DHODHCoQH2 cascade, and MBOAT1/2-mediated monounsaturated fatty acid (MUFA) synthesis (280282)

Milton P, Michael RZ, Christopher MK, Seth JB, Sheldon EL, Menon V, et al

This dual role, where metals can act as both risk factors and therapeutic tools, demonstrates the importance of context when evaluating their health impacts [293]

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hCiPSC treatment resulted in an intermediate phylogenetic distance, suggesting partial restoration of evolutionary lineages (Figure S4D)