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1) Mechanistic gaps in PKD mutationferroptosis link and regulatory networks: Current studies have confirmed ferroptosis-related pathway dysregulation in ADPKD but have failed to clarify the direct molecular link between PKD1/PKD2 mutations and ferroptosis initiation

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As illustrated by the examples discussed throughout this review, the consequences of oxidative stress can manifest in many forms, depending, in part, on the model system under study

World J Gastroenterol 24(8):941948 Weinshilboum RM, Sladek SL (1980) Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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