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Once activated by oxidative stress, NRF2 translocates to the nucleus where it binds to antioxidant response elements (ARE) in the promoter region of genes involved in redox regulation, xenobiotic metabolism, DNA repair, apoptosis, proteostasis, and regulation of inflammation [9]

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Additionally, autoimmune disease also appears to be hallmarked by imbalanced glutathione levels

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, MLH1, POLK, and TMBIM6 ) could discriminate between responders and non-responders to a bevacizumab-based therapy in metastatic BC patients

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