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Of each genotype (Wt, Hz, and Mut), 9, 18, and 10 male mice offspring were used for analysis respectively, in which one sample represents the tissue from 1 male mouse and only one Wt, Hz or Mut mouse from each litter were used to prevent nest-effects

SEED/TIASN/008/2018/G and DST/TMD(EWO)/OWUIS-2018/RS-15(G)) and Technical Education Quality Improvement Program (TEQIP)-III, SSBUICET for providing necessary financial support

[PubMed] [Karger] Ravasi G, Pelucchi S, Greni F, et al

Molsidomine prevents cisplatin-induced hepatotoxicity

It depletes intracellular NAD+, directly poly(ADP-ribosyl)ates PPAR, and impairs both SIRT1 activity and the PPAR-mediated transcription of -oxidation genes, leading to suppressed mitochondrial function and fatty acid oxidation (61,62)

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