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Dysregulated iron homeostasis constitutes the fundamental basis for ferroptosis initiation ( 4.1 Molecular pathways governing ferroptosis cell death Iron is a critical driver of lipid peroxidation and subsequent ferroptosis within cellular environments ( Diminished activity of the cystine/glutamate antiporter (system Xc-) serves as the initial trigger for ferroptosis ( Ferroptosis substrates primarily include polyunsaturated fatty acids (PUFAs, characterized by their abundance of double bonds), free polyunsaturated fatty acids such as oxidized arachidonic acid, and adrenal hormones

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Results After administration of the BPC-157 peptide at all doses (10 g/kg, 1 g/kg, 100 ng/kg, and 10 ng/kg), especially 14 days post-surgery, the diameter of the fistula opening was significantly reduced

10.1200/JCO.2018.36.15_suppl.e13118 JCO

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