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94 The hypoxic microenvironment reduces osteogenic efficacy during bone regeneration, not only by directly reducing cellular activity but also by promoting the accumulation of pro-inflammatory mediators such as reactive oxygen species (ROS)

Microbial copper-resistance systems span copper efflux ( cue , cus , and extrachromosomal efflux systems), copper sequestration (CusF and siderophores), and copper oxidation (mixed copper oxidases and superoxide dismutase mimics)

A previous study by Kang et al

The interactions mostly involve aromatic-aromatic interactions whereby one aromatic moiety is stacked perpendicular to another, allowing favorable interactions between partial positively charged hydrogens on one aromatic moiety with pi electrons in the other

doi: 10.3390/pharmaceutics15030898, 116

elegans , in response to microbial infection, produces several reactive oxygen species (ROS) 67,68