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Alfentanil is demethylated by CYP3A4 and may be a useful CYP3A probe due to the pupillary response to alfentanil (Klees et al., 2005)

COVID-19 patients also display diffused white matter damage, microglial activation, and neuroinflammation at different CNS regions with olfactory neuritis (25%), nodular brainstem encephalitis (31%), and cranial nerve neuritis (6%) 199

In patients with endometriosis, progesterone resistance is observed, possibly related to a decrease in PRB levels [86], which tends to inactivate progesterone target genes, leading to inflammation and deficient estrogen metabolism [87]