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Through this tripartite mechanismanti-inflammatory/antioxidant action, neuroplasticity support, and gutbrain communicationcurcumin addresses the shared pathophysiology underlying chronic metabolic, neurological, and mood disorders

Treatment clues: Small clinical trials of N-acetylcysteine (NAC) , a glutathione precursor, show improvements in irritability and repetitive behaviors

The administration of ginger extract at doses of 100, 200, and 400mg/kg resulted in a reduction in levels of oxidant stress factors such as MDA and PCO, as well as acute inflammatory markers including MPO, TNF-, and PGE2, in rats with acetic acid-induced UC [230]

And it influences the hypothalamic-pituitary-adrenal axis, which connects immune regulation to stress response, an important consideration given that psychological stress is a known trigger for lupus flares