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Seven-Year Orphan Drug Exclusivity (ODE) Drugs designated as orphan drugs by the FDAs Office of Orphan Products Development and approved for the orphan indication earn 7 years of exclusivity that blocks any same-drug approval for the same orphan indication

Probiotic interventions in peritoneal dialysis: a review of underlying mechanisms and therapeutic potentials

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[Rutaceae], restores the AMPK/SIRT1/PPAR- axis, normalizing lipid turnover and reducing hepatic TG accumulation (Zhang et al., 2014)