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Oncotarget 8 (19), 3169231704

The ATP then triggers an ATP-gated cation-selective channel, P2X7-receptor (P2X7R), that opens a pore and initiates K + efflux

Joint treatment of cells with RSL3 + a catechol estrogen (2-OH-E 1 , 2-OH-E 2 , 4-OH-E 1 or 4-OH-E 2 ) strongly abrogated RSL3-induced accumulation of cellular NO (Fig

10.1073/pnas.0605814103 Proc

, Although the rate of glutathione synthesis depends on cysteine availability, cysteine is quickly oxidized to its dimer form cystine in the extracellular space (Figure 1E)