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Studies have shown that local COX-2 overexpression increases the number of CD90 + mouse skeletal stem cells (mSSCs) at the fracture site and targets CD90 + mSSCs to enhance canonical Wnt signal transduction, which results in the promotion of intramembranous osteogenesis and inhibition of intrachondral osteogenesis

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Hypokalaemia may also lead to increased ammoniagenesis, which results in more rapid progression of CKD

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