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demonstrated that increased HIF-1 expression and glycolytic activity in neutrophils suppresses their migration, apoptosis, and the release of ROS, MPO, antimicrobial peptides, and IL-8, effectively preventing excessive neutrophil activation and inflammatory damage during infection (Lu et al., 2021)

Targeting the p53-FOXO4 Axis: In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death

10.1016/j.tem.2017.05.001 186 VerkerkeA

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In contrast, monounsaturated fatty acids (MUFAs) are more able to resist peroxidation and avoid membrane damage (Magtanong et al., 2019)

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