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Description

They warned that the highest concentrations of retained gadolinium were being found in a patients bones, followed by organs (such as the brain, skin, kidney, liver, and spleen)

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While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig

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Bechtel, T

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Brinton et al., 2008

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