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The clinical pictures of vitamin B12 allergy caused by type 1 hypersensitivity that have been revealed with basophile histamine release test and skin prick tests as we have performed in our patient.10 We did not perform basophile histamine release test or specific IgE determination to indicate type 1 hypersensitivity reaction because of positive SPT results of both types of cobalamin preparation

Second, and this is just as important, the cold environment itself creates a hostile setting for any potential microbial contaminants that might have been introduced

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If the anemia is severe in infant, it can lead to seizures and regression of milestones

6 Illnesses that reduce B12 absorption Other problems in either the stomach or the intestine can also stop the B12 absorption process from working