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In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

doi: 10.1177/15579883211011371

Liu T, Wu H, Wei J (2025) Bridging the gap: the neuro-immune axis as a key player in neurodegenerative disorders

The activity of key enzymes like CBS and CGL is regulated by feedback mechanisms and can be influenced by the cellular levels of substrates and products

a-b , human LRP1 ( a ) or mouse Lrp1 ( b ) mRNA levels are showed in indicated tissues

Tehrani Nejad et al., 2022)