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Furthermore, Xing et al

As interest in peptide-based interventions grows, so does the demand for reliable, high-quality compounds available for scientific and investigational use

While supplements can be helpful, injections deliver B12 directly into the bloodstream, bypassing digestion for faster and more complete absorption especially important for those with absorption issues

But given that these side effects are very rare, taking vitamin B12 at bedtime should be fine unless sleep disruption becomes a persistent symptom after taking supplements