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2) The receptor-dependent pathway refers to the direct binding of the LIR motif mitophagy-related receptor to LC3, independent of ubiquitination, and the transport of damaged or redundant mitochondria to autophagosomes to achieve mitochondrial selective autophagic degradation

13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

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