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We repeated these experiments in a separate cohort of tau transgenic mice

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Pep4 is a selected fragment of SLPI (Secretory Leucocyte Protease Inhibitor), whereas Pep4M is a modified form in which the highly reactive cysteine residues were replaced with less reactive methionine residues

The shared pathological mechanisms discussed below are graphically summarized in Figure 1, and the corresponding molecular targets and druggable nodes are illustrated in Figure 2

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These findings align with clinical evidence showing that SIRT1 activators can alleviate fatty liver in MASLD patients, highlighting its pivotal role in lipid-related disease through the AMPK pathway 39,40